Cell Polarity: Formin on the Move
نویسنده
چکیده
Formins assemble actin filaments that are typically arranged in long bundles. A new study has discovered that a fission yeast polarity formin transiently assembles short actin filaments at the cell tip, and then releases from the cortex and rides into the cell interior on filaments within the bundle.
منابع مشابه
Dynamics of the Formin For3p in Actin Cable Assembly
BACKGROUND Formins are a conserved family of actin nucleators responsible for the assembly of diverse actin structures such as cytokinetic rings and filopodia. In the fission yeast Schizosaccharomyces pombe, the formin for3p is necessary for the formation of actin cables, which are bundles of short parallel actin filaments that regulate cell polarity. These filaments are largely organized with ...
متن کاملPolarized growth in budding yeast in the absence of a localized formin.
Polarity is achieved partly through the localized assembly of the cytoskeleton. During growth in budding yeast, the bud cortex and neck localized formins Bni1p and Bnr1p nucleate and assemble actin cables that extend along the bud-mother axis, providing tracks for secretory vesicle delivery. Localized formins are believed to determine the location and polarity of cables, hence growth. However, ...
متن کاملStable and dynamic axes of polarity use distinct formin isoforms in budding yeast.
Bud growth in yeast is guided by myosin-driven delivery of secretory vesicles from the mother cell to the bud. We find transport occurs along two sets of actin cables assembled by two formin isoforms. The Bnr1p formin assembles cables that radiate from the bud neck into the mother, providing a stable mother-bud axis. These cables also depend on septins at the neck and are required for efficient...
متن کاملUnique and Overlapping Functions of Formins Frl and DAAM During Ommatidial Rotation and Neuronal Development in Drosophila.
The noncanonical Frizzled/planar cell polarity (PCP) pathway regulates establishment of polarity within the plane of an epithelium to generate diversity of cell fates, asymmetric, but highly aligned structures, or to orchestrate the directional migration of cells during convergent extension during vertebrate gastrulation. In Drosophila, PCP signaling is essential to orient actin wing hairs and ...
متن کاملRegulation of a formin complex by the microtubule plus end protein tea1p
The plus ends of microtubules have been speculated to regulate the actin cytoskeleton for the proper positioning of sites of cell polarization and cytokinesis. In the fission yeast Schizosaccharomyces pombe, interphase microtubules and the kelch repeat protein tea1p regulate polarized cell growth. Here, we show that tea1p is directly deposited at cell tips by microtubule plus ends. Tea1p associ...
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عنوان ژورنال:
- Current Biology
دوره 16 شماره
صفحات -
تاریخ انتشار 2006